01 - Whisk together buttermilk, salt, garlic powder, onion powder, cayenne pepper, and black pepper in a large bowl until fully combined. Submerge chicken pieces in marinade, ensuring complete coverage. Cover bowl and refrigerate for minimum 2 hours, preferably overnight for optimal flavor penetration.
02 - Combine flour, paprika, salt, black pepper, cayenne pepper, and baking powder in a separate bowl. Mix thoroughly to distribute spices evenly throughout the flour mixture.
03 - Remove chicken from marinade, allowing excess liquid to drip off. Press each piece firmly into flour mixture, ensuring thick, even coating on all sides. Arrange coated pieces on wire rack and let rest for 10 minutes to set coating.
04 - Pour vegetable oil into deep fryer or heavy-bottomed pot to depth of at least 3 inches. Heat oil to 350°F, maintaining temperature throughout frying process.
05 - Carefully lower chicken pieces into hot oil in small batches to prevent overcrowding. Fry for 12-15 minutes, turning occasionally, until golden brown and crispy with internal temperature reaching 165°F.
06 - Transfer fried chicken to wire rack or paper towels to drain excess oil. Let rest for 5 minutes before serving to allow juices to redistribute.